Khemasiri Memorial School was founded on 1 September 1932. It was originally located within the palace of Prince Thiwakon Wongprawat, at No. 3 Khao Road, Samsen Subdistrict, Dusit District, Bangkok.

The school was established by H.S.H. Prince Phoonsrikasem Kasemsri and H.S.H. Princess Sooksrisamorn Kasemsri, using their personal funds, which had been graciously granted by His Royal Highness Prince Mahidol Adulyadej, the Prince Father, for their study visit abroad.

As the founders of the school, H.S.H. Prince Phoonsrikasem Kasemsri and H.S.H. Princess Sooksrisamorn Kasemsri wished to establish a school within the palace grounds, modelled after the public schools of England. They aimed to promote education for young boys and girls of that period. In gratitude for the gracious kindness they had received, they founded the school as an act of charity and named it “Khemasiri Memorial School”, meaning “in remembrance of Kshemsri”.

Khemasiri Memorial School was originally established as a school for female students, offering classes from Prathom 1 to Mathayom 6. H.S.H. Princess Sooksrisamorn Kasemsri, one of the school’s founders, served as the first principal. After her passing on 16 December 1944, H.S.H. Prince Phoonsrikasem Kasemsri continued to oversee the school until his passing on 25 September 1963.

Thereafter, M.R. Torsri (Kasemsri) Kongchumnian carried on the administration of the school, following the principles and ideals of the two founders. In 1967, the school was relocated to its present site at No. 210 Rajavithi Road, Bang Yi Khan Subdistrict, Bang Phlat District, Bangkok, on a 17-rai campus. M.R. Torsri (Kasemsri) Kongchumnian continued to manage the school until 1999, after which Mr. Sombat Kongchumnian administered the school until 2004.

Subsequently, Mrs. Prem-anong (Kongchumnian) Ratnasakha continued the school’s administration, carrying forward the two founders' original vision. She placed great importance on cultivating young women with refined manners and proper conduct, while also promoting academic excellence alongside modern technology, so that students would develop knowledge and skills in technology at an international standard.

During her administration, the school continued to develop its facilities. The 80th Anniversary Khemasiri Memorial Building was constructed; the Phoonsrikasem Building was renovated into a modern library; and the boarding students’ residence was improved to become more comfortable, convenient, and pleasant. Mrs. Prem-anong (Kongchumnian) Ratnasakha administered Khemasiri Memorial School until 2022.

At present, Mr. Khemin Kongchumnian serves as the School Manager. He continues to uphold the original vision of the two founders: to educate young women with the grace and manners of traditional Thai ladies, and to instill in them Buddhist morality and ethics, in accordance with the school philosophy:

“Students are virtuous through culture; students become leaders through knowledge.”

The school remains committed to advancing education by adapting its curriculum to meet the needs of the present day. It integrates modern learning processes and contemporary technology into teaching and learning at every level. The school also encourages students to develop foreign-language skills through cultural exchange with people from other countries. These efforts aim to equip students with essential competencies for daily life, enabling them to become good and capable individuals, responsible leaders in Thai society, and good citizens of the world.